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Merck made a commitment to provide Mectizan for river blindness wherever necessary, for as long as necessary.
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This 20-year-old effort has achieved a number of notable results, including positive health impacts, economic benefits, strengthened health systems, and the empowerment of communities where the delivery and administration of Mectizan are managed.
The areas most severely affected by Guinea worm were three northeastern districts: Kitgum, Moroto, and Kotido.
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At regional level, he served as the founding coordinator for the Africa Christian Health Associations Platform (ACHAP), which has membership of 34 Christian Health Associations from 26 African countries and is currently the ACHAP Board Vice-Chair.
Our company has a long history of environmental stewardship and compliance, but we realize that our strategy and efforts need to evolve in order for us to operate in an increasingly resource-constrained world.
The revised (IHR 2005) established rules and processes that allow the WHO and its member states to identify and respond to international public health emergencies more effectively.
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It is a global partnership which brings together endemic African countries, donors, Non-Governmental Development Organizations (NGDOs), the private sector and the affected communities.
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Cline BL, Hernandez JL, Mather FJ, Bartholomew R, De Maza SN, Rodulfo S, Welborn CA, Eberhard ML, Convit J: Albendazole in the treatment of onchocerciasis: double-blind clinical trial in Venezuela.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Sole G, Remme J, Awadzi K, Accorsi S, Alley ES, Ba O, et al: Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials.
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Figures and illustrate the 26 countries in Africa and the foci in the six endemic Latin American countries, respectively, where mass treatment with Mectizan for onchocerciasis is currently indicated and ongoing; the African countries are color-coded to reflect their inclusion in the former Onchocerciasis Control Programme in West Africa (OCP) or African Programme for Onchocerciasis Control (APOC) regions.
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Patients suspected to have onchocerciasis should be referred to an infectious disease specialist familiar with the management of this mostly sub-Saharan tropical disease.
Schrier SL. Etiology and clinical manifestation of vitamin B12 and folic acid deficiency. UpToDate.
Merck provides additional notice and choices about how personal information is collected, used and disclosed on our Web sites and other online resources that offer social media.
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Personal information about you only will be used and disclosed by Merck and individuals and organizations working on its behalf, in a manner consistent with this policy, other applicable privacy notices, and as explicitly permitted or required by applicable laws, rules and regulations.
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The World Health Organization recommends annual treatments with ivermectin to control the disease, the method currently employed by the two major multilateral efforts to control the disease: the African Programme for Onchocerciasis Control (APOC) and the Onchocerciasis Elimination Programme for the Americas (OEPA).
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Building on this previous work, the objective of this paper is to identify the characteristics of the MDP partnership that have helped it to be sustained, in order to ascertain lessons for the future of onchocerciasis control and the application of partnerships to other public health interventions.
The identification of antiretinal reactivity in CAR syndrome is important both in terms of therapy and the ability to monitor disease progression.
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The complexity of the issues we face, the entrenched nature of the diseases we fight, and the fragility of the healthcare infrastructures we seek to build are all beyond the capability of any single organization or country alone.
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Patients were randomly assigned to receive 200 mg of doxycycline orally every day for 6 weeks or no treatment.
Reich M ( 1997) Assessment of TDR's Contributions to Product Development for Tropical Diseases: The Case of Ivermectin for Onchocerciasis.
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The greatest potential impacts probably lie in the interactions between invasions of vectors or pathogens from tropical and subtropical regions into an expanded receptive zone and increasing urbanization and poverty in developing countries.
Our employees are prohibited from offering healthcare professionals items of personal benefit, such as tickets to sporting events, support for office social events, or gift certificates to stores or golf outings.
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As a result of this work, it was recently announced that parts of Uganda and Sudan have broken the cycle of transmission of onchocerciasis.
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The World Health Organization has found that engaging local people into the process of planning and distributing treatment creates high coverage rates and increases the likelihood of elimination.
The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
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These resources depend on the economic and public health of the society, so that developing countries have far fewer options available to them than do developed countries.
From 1997-2010, at the invitation of the late Prime Minister Meles Zenawi, the Carter Center-supported (EPHTI) worked successfully in partnership with seven Ethiopian universities and the Ethiopia Ministries of Health and Education to address the dangerous void in rural health services for 75 million Ethiopians.
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Adaptation is an ongoing process in human societies, and continuing effort needs to be focused on updating management practices to respond to the changing environment.
Such interventions could build on the local infrastructure and experience gained, and may require the use of an agency such as the MDP, and the partnership mechanisms that have been employed.
Although effective coordinating bodies have sprung up, much of the activity in the field of global health reflects poorly integrated, donor-driven, disease-specific initiatives, often with weak accountability.
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He described the introduction of Mectizan for the treatment for river blindness as “One of those great public health triumphs, not yet entirely complete, but long on its way to being there.
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They show that extremes of both high and low rainfall are correlated with the incidence of mosquito-borne diseases in different environments.
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The constructive partnership with health authorities is also a feature here (Box 3).
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Bacteria from a sinus infection are a common cause; other causes include a stye on the eyelid, bug bites or a recent eyelid injury.
A sign of neurological damage rose in both groups, but it rose more than twice as quickly in the mice that received the placebo than the ones given the active oligo.
March 5: The Carter Center's Mental Health Program, in partnership with the Liberia Ministry of Health and Social Welfare, congratulate the newest class of 21 clinicians, bringing the total number of trained mental health clinicians to 144.
There has been more progress in the last five years than in 100 years of research on the disease.
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Heavy rain or flooding, which leads to increased breeding of mosquitoes, can cause outbreaks of the disease () provided that other conditions are suitable.
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At present there have been no records of reduced immunity involving vector-borne diseases (, ), but observations of the impairment of the immune system by currently recorded groundwater concentrations of mixtures of agricultural chemicals across the United States is a warning sign ().
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Ecuador becomes the second country in the world verified by the World Health Organization as having eliminated river blindness, a milestone in the Carter Center-led effort to eliminate the parasitic disease.
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In that sense, it is just like any other medicine.
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In these diseases it is difficult to determine if the antiretinal antibodies initiated the disease process or if the retinal degeneration occurred first and an immune response was later triggered against selected released retinal antigens.
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Carter Center-supported surveys found trachoma affected 39 percent of children, and the advanced stage of the disease, trichiasis, which requires surgery to prevent blindness, affected an estimated 5 percent of people.
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APOC was originally established to support the control of the disease in African countries affected by river blindness through the development of self-sustaining MECTIZAN distribution programs named CDTI (community-directed treatment with ivermectin) programs.
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